Top Anime 2000-2022: Must-Watch Series
Hey anime fam! It's your boy, back with another epic dive into the world of animation. We're talking about the absolute best anime that graced our screens between the glorious years of 2000 and 2022. That's over two decades of jaw-dropping action, heartwarming stories, and mind-bending plots. So grab your snacks, settle in, and get ready for a journey through some of the most unforgettable anime series ever created. We've scoured the databases, polled the fans, and agonized over every single entry to bring you this definitive list. Whether you're a seasoned otaku or a curious newcomer, there's something here for everyone. Get ready to add some serious titles to your watch list, because we're diving deep into the best anime from 2000 to 2022.
The Golden Age of Shonen: Redefining Action and Emotion
When we talk about the best anime from 2000 to 2022, we absolutely have to start with the titans of the shonen genre. These shows didn't just deliver epic battles; they redefined what it meant to tell a compelling story with powerful character development. One of the undeniable kings of this era is Fullmetal Alchemist: Brotherhood. Released in 2009, this series is a masterpiece of adaptation, faithfully bringing Hiromu Arakawa's incredible manga to life. It tackles complex themes of morality, sacrifice, war, and the true meaning of family with a maturity rarely seen in the genre. The world-building is intricate, the characters are deeply flawed yet incredibly lovable, and the plot is a relentless thrill ride from start to finish. Seriously, the emotional punches this show lands are legendary. You'll laugh, you'll cry, and you'll be on the edge of your seat the entire time. It’s a story about two brothers, Edward and Alphonse Elric, who attempt to use alchemy to bring back their deceased mother. The consequence of this forbidden act leads them on a journey to find the Philosopher's Stone, facing homunculi, corrupt military officials, and the true nature of their world. The narrative weaves together action, adventure, and profound philosophical questions, making it a standout in the best anime from 2000 to 2022 list.
Then there's Attack on Titan. Premiering in 2013, this series took the world by storm with its grim, post-apocalyptic setting and its relentless depiction of humanity fighting for survival against colossal man-eating giants. But calling it just an action show would be a massive understatement. Attack on Titan evolves into a complex political thriller with layers of mystery, betrayal, and existential dread. The animation is top-tier, the action sequences are breathtakingly brutal, and the plot twists are legendary. It consistently keeps you guessing, exploring themes of freedom, oppression, and the cyclical nature of hatred. The characters, particularly Eren Yeager, undergo immense growth and face unimaginable horrors. The sheer scale and ambition of this series are astounding, and its impact on the anime landscape is undeniable. It’s a show that sparks conversation and debate long after the credits roll, cementing its place as a modern classic. The story initially centers on Eren Yeager, Mikasa Ackerman, and Armin Arlert, who join the military to fight the Titans after their hometown is destroyed and Eren's mother is killed. However, as the story progresses, the scope widens dramatically, revealing a much larger and more intricate world with deep historical and political conflicts.
And we can't forget Naruto and Naruto Shippuden. While the original Naruto started in 2002, Shippuden (2007-2017) really fleshed out the epic journey of Naruto Uzumaki. This series is a quintessential example of perseverance, friendship, and overcoming prejudice. Naruto's unwavering belief in himself and his bonds with his friends drive the narrative forward through countless trials and tribulations. The world of ninjas, jutsu, and hidden villages is richly detailed, and the character arcs are incredibly satisfying. The emotional weight of the series, especially during arcs like the Pain arc or the Fourth Great Ninja War, is immense. It’s a story that resonates with millions because it champions the underdog and celebrates the power of connection. The sheer volume of content and the consistent quality of storytelling throughout its long run make it a cornerstone of this era. The journey of a young, ostracized ninja striving to become his village's leader, the Hokage, is filled with iconic fights, memorable characters, and profound lessons about life, loss, and loyalty. This makes it a prime candidate for the best anime from 2000 to 2022.
Other shonen giants like Bleach (2004-2012, with a revival in 2022), One Piece (still ongoing since 1999, but with massive arcs in this period), and Dragon Ball Z Kai (a re-edited version of DBZ) also deserve massive shout-outs for their contributions to the genre during this period. They defined action, adventure, and the spirit of never giving up for a generation of fans.
Psychological Thrillers and Mind-Bending Narratives
Beyond the explosive action, the period from 2000 to 2022 also gave us some of the most thought-provoking and psychologically gripping anime series ever. These shows aren't afraid to delve into the dark corners of the human psyche, explore complex moral dilemmas, and leave you questioning reality itself. A prime example is Death Note. This 2006 thriller is a masterclass in suspense and intellectual combat. The premise is simple yet terrifying: Light Yagami finds a notebook that allows him to kill anyone whose name he writes in it. What follows is a high-stakes game of cat and mouse between Light and the eccentric detective L. Death Note is brilliant because it forces viewers to grapple with questions of justice, power, and morality. Is Light a hero or a villain? Does absolute power corrupt absolutely? The pacing is relentless, the psychological tension is palpable, and the strategic battles of wits are utterly captivating. It’s a show that will have you constantly debating its characters' actions and motivations. The brilliant writing and the iconic characters make it a must-watch for anyone who appreciates a good thriller. The series explores the consequences of playing god and the slippery slope of absolute power. Its compact and impactful storytelling made it a global phenomenon. This is a definite contender for the best anime from 2000 to 2022 for its sheer cleverness.
Then we have Monster. This 2004 psychological thriller follows Dr. Kenzo Tenma, a brilliant Japanese surgeon in Germany who saves the life of a young boy, only to discover years later that the boy has become a ruthless serial killer known as Johan Liebert. Tenma becomes obsessed with finding Johan and undoing the evil he unleashed. Monster is a slow-burn masterpiece, characterized by its incredibly detailed storytelling, complex characters, and mature themes. It explores the nature of evil, the weight of responsibility, and the search for redemption in a world fraught with moral ambiguity. The suspense builds gradually, creating an atmosphere of dread and unease that is incredibly effective. It’s a mature and sophisticated anime that rewards patient viewing with a deeply satisfying and thought-provoking narrative. The vast scope of the story, spanning multiple countries and featuring a huge cast of characters, all interconnected by Johan's enigmatic presence, makes it a truly epic tale of suspense and morality. The detailed examination of human nature and the consequences of choices make it a standout in the best anime from 2000 to 2022.
Don't forget Steins;Gate. This 2011 sci-fi thriller starts off as a quirky comedy about a group of friends who accidentally invent a time machine. However, it quickly spirals into a dark and complex narrative about the Butterfly Effect, fate, and the desperate measures one man will take to save the people he cares about. The first half builds character and sets up the world, while the second half unleashes a torrent of emotional and plot-driven revelations that are absolutely devastating. Steins;Gate is lauded for its brilliant writing, its ability to expertly blend humor with heart-wrenching drama, and its satisfying conclusion. The time travel mechanics are cleverly implemented, and the emotional stakes are incredibly high. It’s a story that will grip you from beginning to end and stay with you long after you’ve finished. The intricate plotting and the powerful emotional core make it a truly special viewing experience. The journey of Okabe Rintaro and his friends as they navigate the treacherous waters of time travel, facing the dire consequences of altering the past, is a testament to masterful storytelling. This series rightfully earns its spot among the best anime from 2000 to 2022.
Other notable mentions in this category include Psycho-Pass (2012) with its dystopian vision of a future society, and Erased (2016) for its compelling mystery and emotional journey. These shows prove that anime can tackle incredibly mature and complex themes with nuance and brilliance.
Slice of Life, Romance, and Character-Driven Dramas
Not all the best anime from 2000 to 2022 are about saving the world or solving murders. Sometimes, the most profound stories come from the everyday lives of ordinary people. The slice of life and romance genres have produced some absolute gems that tug at our heartstrings and offer comforting, relatable experiences. Your Lie in April (2014) is a prime example. This beautiful and heartbreaking series follows Kosei Arima, a young piano prodigy who loses his ability to hear the music after his mother's death. He meets Kaori Miyazono, a free-spirited violinist whose passion for music begins to heal his fractured spirit. The animation is stunning, the music is breathtakingly beautiful, and the emotional impact is immense. It’s a story about grief, love, and finding your voice again. Prepare to shed some tears, guys. The series masterfully portrays the complexities of adolescent relationships, the pressure of talent, and the enduring power of memory and inspiration. The exquisite score and the vibrant visual storytelling make it an unforgettable experience, solidifying its place in the best anime from 2000 to 2022.
Clannad and its sequel Clannad: After Story (2007-2009) are legendary for their emotional depth. This series starts as a romantic comedy but blossoms into one of the most profound explorations of family, loss, and love ever put to anime. After Story, in particular, is renowned for making viewers weep uncontrollably. It follows Tomoya Okazaki as he navigates high school, relationships, and eventually, the challenges of adulthood and parenthood. The character development is phenomenal, and the emotional payoff is unparalleled. It’s a story that reminds us of the beauty and pain of life, and the enduring bonds that hold us together. The transition from a lighthearted high school drama to an incredibly poignant exploration of life's milestones is handled with grace and power. The series teaches us so much about appreciating the small moments and the deep connections we forge. It’s a true masterpiece of emotional storytelling and a definitive entry in the best anime from 2000 to 2022.
For fans of heartwarming and quirky comedies with a touch of romance, Kaguya-sama: Love is War (2020-2022) has been a massive hit. This show hilms a hilarious, high-stakes psychological battle between two genius student council leaders who are too proud to confess their love for each other. Every episode is a masterclass in comedic timing, witty dialogue, and over-the-top scenarios. It's incredibly fun, smart, and surprisingly sweet. The characters are charming, and their escalating attempts to outmaneuver each other are pure gold. It’s the kind of show that will leave you smiling and laughing out loud. The blend of intellectual games, romantic tension, and character-driven humor makes it a fresh and exciting take on the rom-com genre. The inventive visual gags and the sharp writing ensure that every episode is a delightful experience. This makes it a top contender for the best anime from 2000 to 2022 in the comedy and romance categories.
Other fantastic series in this vein include Toradora! (2008) for its excellent portrayal of evolving relationships, Fruits Basket (2019-2021, the reboot) for its deeply emotional story about healing and acceptance, and Violet Evergarden (2018) for its stunning animation and poignant exploration of human connection and grief. These shows offer comfort, joy, and a good cry, proving that character-driven stories are just as impactful as any action-packed epic.
The Rise of Isekai and Fantasy Worlds
No discussion of the best anime from 2000 to 2022 would be complete without mentioning the explosion of the Isekai genre and the continued dominance of epic fantasy. These shows transport viewers to entirely new worlds, filled with magic, adventure, and unique challenges. Re:Zero - Starting Life in Another World (2016-2022) is a standout in the modern Isekai landscape. It takes the familiar trope of being transported to another world and injects it with psychological horror and a brutal 'return by death' mechanic. Subaru Natsuki finds himself in a fantasy world, but instead of gaining overpowered abilities, he's stuck in a loop of dying and resetting. This premise leads to incredibly dark, emotionally taxing, and compelling storytelling. The series explores themes of despair, trauma, and the will to keep going even when facing overwhelming odds. It’s a show that subverts expectations and delivers a mature, often disturbing, but always captivating narrative. The character development, especially Subaru's, is a major draw, as he’s forced to confront his own weaknesses and grow through immense suffering. The world-building is rich, and the supporting cast is well-developed, making the stakes feel incredibly high in every loop. This makes it a defining example of modern Isekai and a strong candidate for the best anime from 2000 to 2022.
On the more traditional fantasy side, Mushoku Tensei: Jobless Reincarnation (2021-2022) has been praised for its high-quality animation, detailed world-building, and complex character journey. It follows Rudeus Greyrat, a shut-in who is reincarnated into a world of magic and swords. While it delves into typical fantasy tropes, it does so with a level of maturity and character depth that sets it apart. The series explores themes of regret, personal growth, and finding purpose. The animation by Studio Bind is absolutely gorgeous, setting a new standard for the genre. The narrative is epic in scope, chronicling Rudeus's life from childhood to adulthood, with all the triumphs and failures that entails. It's a sprawling fantasy epic that feels both familiar and fresh, offering a rich tapestry of adventure and personal discovery. The meticulous attention to detail in both the world and the character's development makes it a truly immersive experience. This ambitious series is a strong contender for the best anime from 2000 to 2022.
We also saw the continued evolution of established fantasy series. Made in Abyss (2017-2022) is a visually stunning and deceptively dark fantasy adventure. It follows Riko and Reg as they descend into a colossal, mysterious chasm known as the Abyss, filled with strange creatures and ancient relics. What starts as a charming exploration quickly turns into a harrowing journey filled with body horror and profound existential questions. The contrast between its beautiful art style and its brutal narrative is striking, making it a unique and unforgettable experience. The world is incredibly imaginative, and the sense of danger is ever-present, pushing the boundaries of what a fantasy adventure can be. The story doesn't shy away from the harsh realities of its world, making the characters' struggles and resilience all the more impactful. The series is a masterclass in atmospheric storytelling and world-building, exploring themes of curiosity, sacrifice, and the unknown. Its unique blend of wonder and terror makes it a standout in the best anime from 2000 to 2022.
Other notable fantasy and Isekai entries include Overlord (2015-2022) for its unique take on an overpowered protagonist, Konosuba: God's Blessing on This Wonderful World! (2016-2017) for its hilarious deconstruction of the genre, and That Time I Got Reincarnated as a Slime (2018-2022) for its compelling world-building and satisfying progression. These series offer diverse takes on escapism and adventure, proving the genre's incredible versatility.
The Ever-Evolving Landscape: Innovation and Global Appeal
Looking back at the best anime from 2000 to 2022, it's clear that the medium has continued to innovate and reach new heights in terms of storytelling, animation quality, and global appeal. We've seen genres blend, new subgenres emerge, and the quality of production skyrocket. The diversity of stories told within this period is astounding, catering to every possible taste. From the gut-wrenching emotional journeys to the intellectually stimulating thrillers, the epic adventures to the quiet moments of reflection, anime has proven itself to be a powerful and versatile storytelling medium. The global reach of anime has also never been greater, with shows reaching millions of fans worldwide through streaming platforms and international collaborations. This era has solidified anime's place not just as a niche interest, but as a major force in global entertainment. It’s a testament to the creativity and passion of the studios, writers, and artists who pour their hearts into these projects. We've only scratched the surface, and there are countless other incredible anime that could have made this list. The sheer volume of high-quality content produced over these 22 years is staggering. So, keep exploring, keep watching, and keep celebrating the amazing world of anime! What are your favorite anime from this period? Let us know in the comments below! This incredible period has given us so many unforgettable experiences, and it's truly exciting to see what the future holds for animation.